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Eye tracking insights dans la recherche médicale Q3 2024.

La technologie de l'Eye tracking a fourni des informations essentielles sur les schémas de recherche visuelle et les capacités de lecture des patients atteints de glaucome, en révélant des différences distinctes dans la métrique du regard et les temps de fixation par rapport aux individus sains. En outre, elle a permis d'élucider le lien mécanique entre le dysfonctionnement mitochondrial et la formation des cils primaires, mettant en évidence des cibles thérapeutiques potentielles pour les ciliopathies. Ces études soulignent la valeur de l'eye tracking pour faire avancer la recherche médicale.

Memory-Guided Saccades and Non-Motor Symptoms Improve after Botulinum Toxin Therapy in Cervical Dystonia

Tihana Gilman Kuric, Zvonimir Popovic, Sara Matosa, Aleksander Sadikov, Vida Groznik, Dejan Georgiev, Alessia Gerbasi, Jagoda Kragujevic, Tea Mirosevic Zubonja, Zdravka Krivdic Dupan, Silva Guljas, Igor Kuric, Stjepan Juric, Ruzica Palic Kramaric & Svetlana Tomic

Background/Objectives: Cervical dystonia (CD) is a condition characterized by involuntary activity of cervical muscles, which is often accompanied by various non-motor symptoms. Recent studies indicate impaired saccadic eye movements in CD. Local administration of botulinum toxin type A (BoNT/A), which causes temporary paralysis of the injected muscle, is the first-line treatment of focal dystonia, including CD. To our knowledge, concurrent observation of the effect of BoNT/A on smooth eye movements, voluntary saccades, memory-guided saccades, and antisa...

Modeling Sensor-based Vigilance Decrement in the Healthcare Environment

Jiaxin Li, Veronika Kettel, Elizabeth A. Higgins, Chaowei Xiao, Younghoon Kwon, Michael Meno, Victoria A. Roach & Ji-Eun Kim

Vigilance refers to an individual’s ability to maintain attention over time. Vigilance decrement is particularly concerning in clinical environments where shift work and long working hours are common. This study identifies significant factors and indicators for predicting and monitoring individuals’ vigilance decrement. We enrolled 11 participants and measured their vigilance levels by recording their reaction times while completing the Psychomotor Vigilance Test. Additionally, we measured participants’ physiological responses and collected their sleep d...

Experimental Method for Identifying Regions of Use of a Progressive Power Lens Using an Eye-Tracker: Validation Study

Clara Benedi-Garcia, Pablo Concepcion-Grande, Eva Chamorro, Jose Miguel Cleva & José Alonso

Power distribution of progressive power lenses provides usable regions based on power distribution analysis. However, recent studies demonstrated that these regions are not always used for certain tasks as predicted. This work determines the concordance between the actual region of lens use and compares it with the theoretically located regions. The pupil position of 26 subjects was recorded using an eye-tracking system (Tobii-Pro-Glasses 3) at distance and near-reading tasks while wearing a general use progressive power lens. Subjects were asked to read...

Skip-AttSeqNet: Leveraging skip connection and attention-driven Seq2seq model to enhance eye movement event detection in Parkinson’s disease

Xin Wang, Lizhou Fan, Haiyun Li, Xiaochan Bi, Wenjing Jiang & Xin Ma

To address the limitations of traditional algorithms in detecting eye movement events, particularly in Parkinson’s disease (PD) patients, this study introduces Skip-AttSeqNet. It presents an innovative approach combining skip-connected, one-dimensional convolutional neural networks with an attention-enhanced, bidirectional long short-term memory network. This hybrid architecture significantly advances smooth pursuit (SP) event detection, as evidenced by its performance on both the GazeCom dataset and a unique dataset of PD patient eye movements. Key inno...

Using eye tracking to assess learning of a multifunction prosthetic hand: an exploratory study from a rehabilitation perspective

Wendy Hill & Helen Lindner

Eye tracking technology not only reveals the acquisition of visual information at fixation but also has the potential to unveil underlying cognitive processes involved in learning to use a multifunction prosthetic hand. It also reveals gaze behaviours observed during standardized tasks and self-chosen tasks. The aim of the study was to explore the use of eye tracking to track learning progress of multifunction hands at two different time points in prosthetic rehabilitation.

Assessment of silent reading ability among glaucoma patients using an eye tracking system with horizontally scrolling text

Hiroshi Yokoyama, Masashi Takata, Hiroyuki Kanda, Yoichi Okita & Fumi Gomi

There have been many reports suggesting that glaucoma patients with visual field defects may have decreased silent reading ability compared with individuals without glaucoma. This study used an eye tracking system to assess the ability of glaucoma patients to silently read horizontally scrolling text. Glaucoma patients who met the following criteria were recruited: age of ≤ 70 years, at least one eye with a 10 − 2 threshold on standard automated perimetry, a mean deviation value of n 4.0 dB or less, and corrected decimal visual acuity of 0.7 or better in...

Primary cilia formation requires the Leigh syndrome–associated mitochondrial protein NDUFAF2

Chien-Hui Lo, Zhiquan Liu, Siyu Chen, Frank Lin, Andrew R. Berneshawi, Charles Q. Yu, Euna B. Koo, Tia J. Kowal, Ke Ning, Yang Hu, Won-Jing Wang, Y. Joyce Liao & Yang Sun

Mitochondria-related neurodegenerative diseases have been implicated in the disruption of primary cilia function. Mutation in an intrinsic mitochondrial complex I component NDUFAF2 has been identified in Leigh syndrome, a severe inherited mitochondriopathy. Mutations in ARMC9, which encodes a basal body protein, cause Joubert syndrome, a ciliopathy with defects in the brain, kidney, and eye. Here, we report a mechanistic link between mitochondria metabolism and primary cilia signaling. We discovered that loss of NDUFAF2 caused both mitochondrial and cili...

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