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Eye tracking insights in medical research Q3 2024

Eye tracking technology has provided critical insights into the visual search patterns and reading abilities of glaucoma patients, revealing distinct differences in gaze metrics and fixation times compared to healthy individuals. Additionally, it has elucidated the mechanistic link between mitochondrial dysfunction and primary cilia formation, highlighting potential therapeutic targets for ciliopathies. These studies underscore the value of eye tracking in advancing medical research.

  1. 1. Memory-Guided Saccades and Non-Motor Symptoms Improve after Botulinum Toxin Therapy in Cervical Dystonia
  2. 2. Modeling Sensor-based Vigilance Decrement in the Healthcare Environment
  3. 3. Experimental Method for Identifying Regions of Use of a Progressive Power Lens Using an Eye-Tracker: Validation Study
  4. 4. Skip-AttSeqNet: Leveraging skip connection and attention-driven Seq2seq model to enhance eye movement event detection in Parkinson’s disease
  5. 5. Characterization of Gaze Metrics and Visual Search Pattern Among Glaucoma Patients While Viewing real-world Images
  6. 6. Using eye tracking to assess learning of a multifunction prosthetic hand: an exploratory study from a rehabilitation perspective
  7. 7. Assessment of silent reading ability among glaucoma patients using an eye tracking system with horizontally scrolling text
  8. 8. Primary cilia formation requires the Leigh syndrome–associated mitochondrial protein NDUFAF2

Memory-Guided Saccades and Non-Motor Symptoms Improve after Botulinum Toxin Therapy in Cervical Dystonia

September 26, 2024Tihana Gilman Kuric, Zvonimir Popovic, Sara Matosa, Aleksander Sadikov, Vida Groznik, Dejan Georgiev, Alessia Gerbasi, Jagoda Kragujevic, Tea Mirosevic Zubonja, Zdravka Krivdic Dupan, Silva Guljas, Igor Kuric, Stjepan Juric, Ruzica Palic Kramaric & Svetlana Tomic

Background/Objectives: Cervical dystonia (CD) is a condition characterized by involuntary activity of cervical muscles, which is often accompanied by various non-motor symptoms. Recent studies indicate impaired saccadic eye movements in CD. Local administration of botulinum toxin type A (BoNT/A), which causes temporary paralysis of the injected muscle, is the first-line treatment of focal dystonia, including CD. To our knowledge, concurrent observation of the effect of BoNT/A on smooth eye movements, voluntary saccades, memory-guided saccades, and antisa...

  • Tobii Pro TX-300

Modeling Sensor-based Vigilance Decrement in the Healthcare Environment

September 25, 2024Jiaxin Li, Veronika Kettel, Elizabeth A. Higgins, Chaowei Xiao, Younghoon Kwon, Michael Meno, Victoria A. Roach & Ji-Eun Kim

Vigilance refers to an individual’s ability to maintain attention over time. Vigilance decrement is particularly concerning in clinical environments where shift work and long working hours are common. This study identifies significant factors and indicators for predicting and monitoring individuals’ vigilance decrement. We enrolled 11 participants and measured their vigilance levels by recording their reaction times while completing the Psychomotor Vigilance Test. Additionally, we measured participants’ physiological responses and collected their sleep d...

  • Tobii Pro X3-120
  • Tobii Pro Lab

Experimental Method for Identifying Regions of Use of a Progressive Power Lens Using an Eye-Tracker: Validation Study

September 20, 2024Clara Benedi-Garcia, Pablo Concepcion-Grande, Eva Chamorro, Jose Miguel Cleva & José Alonso

Power distribution of progressive power lenses provides usable regions based on power distribution analysis. However, recent studies demonstrated that these regions are not always used for certain tasks as predicted. This work determines the concordance between the actual region of lens use and compares it with the theoretically located regions. The pupil position of 26 subjects was recorded using an eye-tracking system (Tobii-Pro-Glasses 3) at distance and near-reading tasks while wearing a general use progressive power lens. Subjects were asked to read...

  • Tobii Pro Glasses 3

Skip-AttSeqNet: Leveraging skip connection and attention-driven Seq2seq model to enhance eye movement event detection in Parkinson’s disease

September 12, 2024Xin Wang, Lizhou Fan, Haiyun Li, Xiaochan Bi, Wenjing Jiang & Xin Ma

To address the limitations of traditional algorithms in detecting eye movement events, particularly in Parkinson’s disease (PD) patients, this study introduces Skip-AttSeqNet. It presents an innovative approach combining skip-connected, one-dimensional convolutional neural networks with an attention-enhanced, bidirectional long short-term memory network. This hybrid architecture significantly advances smooth pursuit (SP) event detection, as evidenced by its performance on both the GazeCom dataset and a unique dataset of PD patient eye movements. Key inno...

  • Tobii Pro X2-60 / X2-30

Characterization of Gaze Metrics and Visual Search Pattern Among Glaucoma Patients While Viewing real-world Images

September 6, 2024Sangeetha Nagarajan, Najiya Sundus K. Meethal, Johan J.M. Pel, Rashima Asokan, Kalpa Negiloni & Ronnie George

We quantified and compared the gaze metrics during target-oriented visual search tasks between glaucoma and healthy controls. Based on a mathematical concept we showed that due to glaucoma, focal search becomes prominent over global search.

  • Tobii Pro X3-120

Using eye tracking to assess learning of a multifunction prosthetic hand: an exploratory study from a rehabilitation perspective

September 1, 2024Wendy Hill & Helen Lindner

Eye tracking technology not only reveals the acquisition of visual information at fixation but also has the potential to unveil underlying cognitive processes involved in learning to use a multifunction prosthetic hand. It also reveals gaze behaviours observed during standardized tasks and self-chosen tasks. The aim of the study was to explore the use of eye tracking to track learning progress of multifunction hands at two different time points in prosthetic rehabilitation.

  • Tobii Pro Glasses 2
  • Tobii Pro Lab

Assessment of silent reading ability among glaucoma patients using an eye tracking system with horizontally scrolling text

August 15, 2024Hiroshi Yokoyama, Masashi Takata, Hiroyuki Kanda, Yoichi Okita & Fumi Gomi

There have been many reports suggesting that glaucoma patients with visual field defects may have decreased silent reading ability compared with individuals without glaucoma. This study used an eye tracking system to assess the ability of glaucoma patients to silently read horizontally scrolling text. Glaucoma patients who met the following criteria were recruited: age of ≤ 70 years, at least one eye with a 10 − 2 threshold on standard automated perimetry, a mean deviation value of n 4.0 dB or less, and corrected decimal visual acuity of 0.7 or better in...

  • Tobii Pro Spectrum
  • Tobii Pro Lab

Primary cilia formation requires the Leigh syndrome–associated mitochondrial protein NDUFAF2

July 2, 2024Chien-Hui Lo, Zhiquan Liu, Siyu Chen, Frank Lin, Andrew R. Berneshawi, Charles Q. Yu, Euna B. Koo, Tia J. Kowal, Ke Ning, Yang Hu, Won-Jing Wang, Y. Joyce Liao & Yang Sun

Mitochondria-related neurodegenerative diseases have been implicated in the disruption of primary cilia function. Mutation in an intrinsic mitochondrial complex I component NDUFAF2 has been identified in Leigh syndrome, a severe inherited mitochondriopathy. Mutations in ARMC9, which encodes a basal body protein, cause Joubert syndrome, a ciliopathy with defects in the brain, kidney, and eye. Here, we report a mechanistic link between mitochondria metabolism and primary cilia signaling. We discovered that loss of NDUFAF2 caused both mitochondrial and cili...

  • Tobii Pro Spectrum
  • Tobii Pro Lab
  1. 1. Memory-Guided Saccades and Non-Motor Symptoms Improve after Botulinum Toxin Therapy in Cervical Dystonia
  2. 2. Modeling Sensor-based Vigilance Decrement in the Healthcare Environment
  3. 3. Experimental Method for Identifying Regions of Use of a Progressive Power Lens Using an Eye-Tracker: Validation Study
  4. 4. Skip-AttSeqNet: Leveraging skip connection and attention-driven Seq2seq model to enhance eye movement event detection in Parkinson’s disease
  5. 5. Characterization of Gaze Metrics and Visual Search Pattern Among Glaucoma Patients While Viewing real-world Images
  6. 6. Using eye tracking to assess learning of a multifunction prosthetic hand: an exploratory study from a rehabilitation perspective
  7. 7. Assessment of silent reading ability among glaucoma patients using an eye tracking system with horizontally scrolling text
  8. 8. Primary cilia formation requires the Leigh syndrome–associated mitochondrial protein NDUFAF2
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