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Eye tracking in medical mesearch: Q4 2025 Insights

Q4 2025 medical research publications highlighted the significant role of eye tracking technology in advancing our understanding of various medical conditions and therapeutic interventions. Eye tracking provided critical insights into prosthetic control learning, autism diagnosis, amblyopia treatment, stroke rehabilitation, and vision loss. The technology enabled researchers to objectively measure and analyze gaze behavior, eye movements, and visual strategies, leading to more accurate diagnoses and effective treatment strategies.

  1. 1. Gaze strategy and sense of ownership in learning prosthetic control: a comparative study using wearable eye tracking
  2. 2. Machine learning-based diagnosis of autism spectrum disorder in children and adolescents using eye-tracking data: a systematic review and meta-analysis
  3. 3. Visual ERP-based brain–computer interface use with severe physical, speech and eye movement impairments: case studies
  4. 4. The impact of dorsolateral prefrontal cortex stimulation on attention networks and saccadic performance in adults with amblyopia
  5. 5. Quantifying User Engagement During an Upper Limb Rehabilitation Task
  6. 6. Lens-Viewpoint Extraction Method for Personalized Progressive Addition Lens Fitting
  7. 7. The Preferred Retinal Locus for Reading in Central Vision Loss
  8. 8. Greening Schoolyards to Improve Child Health: A Quasi-Experimental Study Protocol in Belgian and Dutch Primary Schools
  9. 9. Effects of Cataracts Severities on Eye Movements and Task Performance During a Visual Search Task Through Virtual Reality Simulations
  10. 10. Fixation Preference in Intermittent Exotropia Quantified Using a Wearable Eye Tracker
  11. 11. Objective Analysis of Reading Ability Using an Eye Tracker in Intermittent Exotropia
  12. 12. Investigating brain maturation, neurodevelopmental and psychiatric outcomes in individuals with early-onset liver disease: protocol of a single-centre observational study

Gaze strategy and sense of ownership in learning prosthetic control: a comparative study using wearable eye tracking

December 28, 2025Manabu Yoshimura, Hiroshi Kurumadani, Shota Date, Junya Hirata, Tomotaka Ito, Katsutoshi Senoo, Kozo Hanayama & Toru SunagawaJournal of NeuroEngineering and Rehabilitation

BackgroundProsthetic control requires not only motor execution but also the development of adaptive visual strategies. Myoelectric prostheses provide limited sensory feedback and therefore rely more heavily on visual monitoring. However, learning-related changes in gaze behavior—including fixation patterns and physiological indices such as blink rate—remain underexplored. This study aimed to investigate how gaze behavior changes and the sense of ownership change during the learning of body-powered and myoelectric prosthetic control, and how these effects...

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Machine learning-based diagnosis of autism spectrum disorder in children and adolescents using eye-tracking data: a systematic review and meta-analysis

December 27, 2025Wenhao Han, Xinyu Yang, Xin Li, Jiacheng Wang, Juan Liu & Wei PangInternational Journal of Medical Informatics

Objective Eye-tracking technology has been increasingly investigated as an objective approach for distinguishing individuals with Autism Spectrum Disorder (ASD) from typically developing (TD) individuals. Artificial intelligence and machine learning (ML) methods have been widely applied to support ASD diagnosis and treatment, and prior studies suggest that ML models leveraging eye-tracking data can achieve high diagnostic accuracy. This systematic review and meta-analysis aimed to evaluate the diagnostic performance of machine-learning models using eye-t...

Visual ERP-based brain–computer interface use with severe physical, speech and eye movement impairments: case studies

December 22, 2025Arne Van Den Kerchove, Juliette Meunier, Marie de Moura, Alixe Willemssens, Dorien Geeurickx, Edward Schiettecatte, Philip Van Damme, Hakim Si-Mohammed, François Cabestaing, Etienne Allart & Marc M. Van HulleJournal of NeuroEngineering and Rehabilitation

BackgroundIndividuals who experience severe speech and physical impairment face significant challenges in communication and daily interaction. Visual brain–computer interfaces (BCIs) offer a potential assistive solution, but their usability is limited when facing restrictions in eye motor control, gaze redirection and fixation. This study investigates the feasibility of a gaze-independent visual oddball BCI for use as an augmentative and alternative communication (AAC) device in the presence of limited eye motor control.MethodsSeven participants with var...

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The impact of dorsolateral prefrontal cortex stimulation on attention networks and saccadic performance in adults with amblyopia

December 9, 2025Mohammad Maeiyat, Soomaayeh Heysieattalab & Khalil EsmaeilpourVision Research

Amblyopia, characterized by monocular visual deficits and impaired binocularity, attention, and oculomotor control, is often considered untreatable in adulthood due to reduced neuroplasticity. Conventional therapies target children within the critical period. This study investigated transcranial direct current stimulation (tDCS) over the dorsolateral prefrontal cortex (dlPFC) as a novel intervention to modulate attentional networks and saccadic performance in adults with amblyopia. Thirty adults (20--35 years) with unilateral amblyopia were randomized in...

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Quantifying User Engagement During an Upper Limb Rehabilitation Task

December 3, 2025Yawen Zhang, Haofei Wang & Bertram E. ShiIEEE Transactions on Neural Systems and Rehabilitation Engineering

Enhancing patient engagement is essential for effective post-stroke robotic rehabilitation, yet limited effort has been made towards modulating and quantifying patient engagement during therapy. To Bridge this gap, we introduce a virtual reality (VR)-integrated robot-assisted system for upper limb rehabilitation, which innovatively enables simultaneous modulation and monitoring of user engagement in a line tracing task. Modulation is governed by two parameters: shape complexity and force noise disturbance level. Our system estimates engagement using phys...

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Lens-Viewpoint Extraction Method for Personalized Progressive Addition Lens Fitting

December 1, 2025Yating Yang, Xiaoqin Chen, Zhichao Deng, Jianchun Mei, Yutong Li, Xingyi Guo, Peiran Zhou, Lihua Li & Qing YeTranslational Vision Science & Technology

Purpose: To validate the accuracy of a lens-viewpoint extraction method and demonstrate its feasibility for tracking users' visual behavior on progressive addition lenses (PALs). This aims to provide a quantifiable fitting solution for PAL wearers in the future. Methods: We evaluated a method using eye-tracking technology to extract the viewpoint on the lens, implemented with a self-made setup. Accuracy verification experiments were performed using a mechanical artificial eye, and a clinical test on 10 subjects was performed to assess the accuracy of the...

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The Preferred Retinal Locus for Reading in Central Vision Loss

November 1, 2025Arda Fidanci, Colin S. Flowers, Christian Larson, Stephen A. Engel & Gordon E. LeggeInvestigative Ophthalmology & Visual Science

Purpose: People with central vision loss (CVL) often adopt a preferred retinal locus (PRL) for fixation outside the region of central loss. However, it is unknown how often the fixational PRL (fPRL) is used in reading. Here, we assessed if the reading PRL is in the same location as the fPRL.Methods: Participants read text on a computer screen. Reading was randomly interrupted by blanking the screen, and participants reported the word being read when the blanking occurred. The location of this word was compared to the fPRL location, measured with an eye t...

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Greening Schoolyards to Improve Child Health: A Quasi-Experimental Study Protocol in Belgian and Dutch Primary Schools

November 1, 2025Bo H. W. van Engelen, Lore Verheyen, Bjorn Winkens, Michelle Plusquin, Robert Malina & Onno C. P. van SchayckInternational Journal of Environmental Research and Public Health

Background: Childhood obesity and mental health problems are major public health concerns worldwide. Early-life exposure to green spaces has been shown to promote physical activity, reduce obesity risk, and improve cognitive and emotional development. Schoolyards offer a unique opportunity to promote health, as children spend a large proportion of their time at school. Methods: This quasi-experimental protocol study investigates the effects of transforming gray schoolyards into biodiverse green spaces on children’s health and well-being. Four primary sch...

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Effects of Cataracts Severities on Eye Movements and Task Performance During a Visual Search Task Through Virtual Reality Simulations

November 1, 2025Jesse W. Grootjen, Yannick Weiss, Tobias Daniel, Fabian Kahman & Sven MayerProceedings of the 24th International Conference on Mobile and Ubiquitous Multimedia

Visual impairments, such as cataracts, pose a global challenge with preventable cases and unaddressed issues due to limited eye care understanding. In this work, we investigate cataracts using a virtual reality simulation, exploring its impact on a visual search task and investigating the correlations between eye movement features and the severity of the simulation. We simulated cataract progression in one or both eyes through two studies utilizing virtual reality and eye tracking. We analyzed the impact on task performance and eye movements and found th...

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Fixation Preference in Intermittent Exotropia Quantified Using a Wearable Eye Tracker

November 1, 2025John R Economides & Jonathan C HortonAmerican Journal of Ophthalmology

PURPOSE: To measure eye fixation preference in patients with intermittent exotropia using a wearable binocular eye tracker that records the position of each globe within the orbit.DESIGN: Prospective assessment validity analysis.SUBJECTS: Forty patients referred to a single pediatric ophthalmologist for evaluation of intermittent exotropia.METHODS: Ambulatory patients wore eye tracking glasses for up to 12 hours to monitor their ocular alignment while carrying out their usual daily activities. Histograms were prepared of each eye's horizontal position as...

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Objective Analysis of Reading Ability Using an Eye Tracker in Intermittent Exotropia

November 1, 2025Dong Hyun Kim, Jeong-Min Hwang & Hee Kyung YangLife

Background/Objectives: This study's objective was to analyze the reading ability in patients with intermittent exotropia using an eye tracker and determine how the clinical characteristics of intermittent exotropia may affect reading ability. Methods: We compared the reading speed (LPS; letters per second) of 25 intermittent exotropia patients to 25 age-matched normal controls who were 13 years old or older with best-corrected visual acuities of ≥20/25. Correlations between reading ability and clinical characteristics of intermittent exotropia were evalu...

Investigating brain maturation, neurodevelopmental and psychiatric outcomes in individuals with early-onset liver disease: protocol of a single-centre observational study

November 1, 2025Melanie Ehrler, Megan Earl, Jemma Day, Jonathan O’Muircheartaigh, Luke Mason, Nicolaas Puts, Flavio Dell’Acqua, Charlotte E Blackmore, Grainne M McAlonan & Marianne SamynBMJ Open

INTRODUCTION: Early-onset chronic liver disease (CLD) and its subsequent clinical progression have systemic impact. Its trajectory coincides with critical periods of brain development. In this study, we will test the hypothesis that early-onset CLD is associated with neurodevelopmental and psychiatric symptoms and delineate their neurobiological underpinnings through multimodal neuroimaging.METHODS AND ANALYSIS: This study will recruit 100 patients with biliary atresia and 50 patients with other types of early-onset CLD, aged between 6 and 30 years, unde...

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  1. 1. Gaze strategy and sense of ownership in learning prosthetic control: a comparative study using wearable eye tracking
  2. 2. Machine learning-based diagnosis of autism spectrum disorder in children and adolescents using eye-tracking data: a systematic review and meta-analysis
  3. 3. Visual ERP-based brain–computer interface use with severe physical, speech and eye movement impairments: case studies
  4. 4. The impact of dorsolateral prefrontal cortex stimulation on attention networks and saccadic performance in adults with amblyopia
  5. 5. Quantifying User Engagement During an Upper Limb Rehabilitation Task
  6. 6. Lens-Viewpoint Extraction Method for Personalized Progressive Addition Lens Fitting
  7. 7. The Preferred Retinal Locus for Reading in Central Vision Loss
  8. 8. Greening Schoolyards to Improve Child Health: A Quasi-Experimental Study Protocol in Belgian and Dutch Primary Schools
  9. 9. Effects of Cataracts Severities on Eye Movements and Task Performance During a Visual Search Task Through Virtual Reality Simulations
  10. 10. Fixation Preference in Intermittent Exotropia Quantified Using a Wearable Eye Tracker
  11. 11. Objective Analysis of Reading Ability Using an Eye Tracker in Intermittent Exotropia
  12. 12. Investigating brain maturation, neurodevelopmental and psychiatric outcomes in individuals with early-onset liver disease: protocol of a single-centre observational study
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